Shenzhen Shijingu Technology Co., Ltd.
Business type: Manufacturer
Telephone : 86-180-38192039
Baoguan Road, Buji Town, Longang District, Shenzhen, China
|Place of Origin:||Email: email@example.com|
|Brand Name:||Legal Sarms|
|Minimum Order Quantity:||50 grams|
|Price:||contact us for current prices|
|Packaging Details:||customized packaging suits you best|
|Delivery Time:||4-7 working days|
|Payment Terms:||Western Union, MoneyGram, T/T, Bitcoin|
|SR9011 Purity:||99% Min||SR9011 Shipping:||Discreet Packing Methods|
SR9011 CAS 1379686-30-2 Sarm Pharmaceutical Raw Material Fitness Nutrition
Cas No 1379686-29-9
Molucelar weight 479.03524
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
How to Use SR9011
In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
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